Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13919
Title: Antioxidant, Antimicrobial and Cytotoxic Activities of Salvia verticillata L. Extracts
Authors: Barjaktarevic, Ana
Ćirović N.
Arsenijevic, Nebojsa
Volarevic, Vladislav
Markovic B.
Mitić V.
Stankov Jovanovic, Vesna
Cupara S.
Journal: Indian Journal of Pharmaceutical Sciences
Issue Date: 1-Nov-2021
Abstract: Salvia verticillata L. is a well-known plant from the family Lamiaceae. The purpose of this research was to analyze the cytotoxic, antioxidant and antimicrobial activities of chloroform and petroleum ether root extracts of Salvia verticillata. The total content of phenolic compounds and flavonoids were determined in both of the extracts. The antioxidant activity was estimated in vitro using different assays. The antimicrobial potential was tested against different test strains using micro-well dilution assay. The cytotoxic activity was evaluated on epithelial, human breast cancer cell line MDA-MB-231 and human colorectal carcinoma cell line HCT 116 by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The extracts showed similar antioxidant activity. The values for the antimicrobial activity differed depending on the microbial strain as well on the solvent used. There were significant differences in cytotoxic effect on investigated cell lines depending of the concentration. Half maximal inhibitory concentration value for chloroform extract was 77.16 μg/ml for MDA-MB-231 cell line and 105.08 μg/ml for the HCT 116 cell line. Half maximal inhibitory concentration value for petroleum ether extract was 30.90 μg/ml for MDAMB- 231 cell line and 44.28 μg/ml for the HCT 116 cell line.
URI: https://scidar.kg.ac.rs/handle/123456789/13919
Type: Article
DOI: 10.36468/pharmaceutical-sciences.883
ISSN: 0250474X
SCOPUS: 85122272003
Appears in Collections:Faculty of Medical Sciences, Kragujevac
[ Google Scholar ]

Page views(s)

33

Downloads(s)

1

Files in This Item:
File Description SizeFormat 
10.36468-pharmaceutical-sciences.883.pdf661.5 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.