Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13940
Title: Influence of biological markers on overall survival in surgically treated patients with non-small cell lung cancer
Authors: Lončarević O.
Loncarevic, Slobodan
Vekic, Berislav
DJUKANOVIĆ L.
Vukovic J.
Rancic, Nemanja
Issue Date: 2021
Abstract: Background/Aim. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and a leading cause of cancer-related deaths. The aim of this study was to assess the impact of biological markers on the overall sur-vival rate in surgically treated NSCLC patients who received adjuvant chemotherapy and/or radiation therapy. Methods. This retrospective case series study included patients with NSCLC treated in the period between 2008 and 2017 at the Pulmonology Clinic and the Clinic for Chest Surgery, Mili-tary Medical Academy, Belgrade, Serbia. The survival analy-sis performed was based on immunohistological findings, histology type, and tumor, node, metastasis (TNM) stages. Results. The mortality rate was higher in the adenocarci-noma patient group compared to the squamous cell carci-noma group, albeit without statistical significance (58.3% vs. 31.2%, respectively; p = 0.175). Overall survival was shorter in the adenocarcinoma patient group compared to the squamous cell carcinoma group by approximately 750 days. Likewise, overall survival was shorter in the adenocarcino-ma patient group compared to the squamous cell carcinoma group for CD31 positive (p = 0.029), p-63 positive (p = 0.049), MMP-9 positive (p = 0.032), and matrix metallopro-teinase (MMP)-2 positive patients (p = 0.016). Conclusion. Adenocarcinoma is a more aggressive cancer type compared to squamous cell carcinoma with shorter overall survival. Our research showed a poorer overall survival in the adeno-carcinoma group of patients compared to the squamous cell carcinoma group in CD31, p-63, MMP-9, and MMP-2 posi-tive patients.
URI: https://scidar.kg.ac.rs/handle/123456789/13940
Type: article
DOI: 10.2298/VSP191030035L
ISSN: 0042-8450
SCOPUS: 2-s2.0-85121619729
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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