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Title: Evaluation of biological activities of acetone extract of the mushroom leccinum scabrum
Authors: Tubić Vukajlović Jovana
Kosanic, Marijana
Ranković Branislav
Stanojkovic, Tatjana
Markovic Aleksandra
Grujičić, Darko
Djelić Ninoslav
Radakovic Milena
Milošević-Đorđević, Olivera
Issue Date: 2021
Abstract: Bioactivity of acetone extract of Leccinum scabrum was evaluated. Antioxidant activity was evaluated by free radical scavenging activity, reducing power and determination of total phenolic content. The microdilution plate method was used to detect antimicrobial activity. Cytotoxic activity was tested by MTT assay. Genotoxic potential was evaluated by comet assay. Results showed a stronger free radical scavenging activity, but the reducing power was less pronounced. The total content of phenols in the extract was 14.91 µg PE/mg. The minimum inhibitory concentration related to the tested microorganisms fluctuated in the range 0.039-10 mg/mL. The most sensitive was Bacillus cereus. A strong cytotoxic activity was revealed with IC50 values ranging between 73.64 and 200.00 µg/mL, among which HeLa was the most sensitive. Results showed that the extract was not genotoxic and it decreased the H2O2-induced GDI values in comparison to the positive control. L. scabrum possesses bioactivities such as antioxidant, antimicrobial, cytotoxic, no genotoxic and protective against H2O2, and in the highest tested concentration it showed a synergistic activity.
Type: article
DOI: 10.31925/FARMACIA.2021.5.22
ISSN: 0014-8237
SCOPUS: 2-s2.0-85120774323
Appears in Collections:Faculty of Science, Kragujevac

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