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Title: Contrasting roles of the galectin-3 in the schizophrenia onset, clinical presentation, and somatic comorbidity
Authors: Borovcanin, Milica
Radosavljevic, Gordana
Pantic, Jelena
Milovanovic, Jelena
Mijailovic, Natasa
Arsenijevic A.
Arsenijevic, Nebojsa
Issue Date: 2021
Abstract: The role of the Galectin-3 (Gal-3) has already been explored in various somatic diseas-es, considering its engagement in infection, acute and chronic inflammation, and autoimmunity. Additionally, it has been recognized that Gal-3 is included in neuroinflammation and neurodegener-ation, so we presented the possibility for its involvement in neuroprogression in schizophrenia. Gal-3 possibly participates in the early life programming of schizophrenia, also in the specific response to viral infections as a “second hit” later in life, and as a part of a unique systemic somatic dysfunction leading to the specific mental changes. In this review, we would like to put all these previous observations of Gal-3 properties in the context of schizophrenia onset, clinical symptoms presentation, frequent somatic comorbid states, and future options for Gal-3 centered treatment in schizophrenia.
Type: review
DOI: 10.2174/1568026621666210611162420
ISSN: 1568-0266
SCOPUS: 2-s2.0-85116328168
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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