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Title: The role of vitamin A and vitamin D in modulation of the immune response with a focus on innate lymphoid cells
Authors: Dzopalic, Tanja
Nedeljković B.
Jurisic, Vladimir
Journal: Central European Journal of Immunology
Issue Date: 1-Jan-2021
Abstract: The immune system with its numerous and complex interactions helps to protect the host from pathogenic microorganisms, and enables cleaning of damaged tissues. It is also associated with constant monitoring of the appearance of malignant cells and their elimination that can occur in the human body. Such a role depends on many factors including adequate intake of nutrients, including vitamins. The effect of vitamin supplementation on the modulation of the immune response has always been the focus of numerous studies. Vitamins A and D have been shown to have the greatest immune-modulatory effect. In this review, we discuss and consider the possible roles of vitamins A and D on the immune response through innate and adaptive immune cells, with special focus on the cell population recently characterized as innate lymphoid cells. Recent literature data indicate that vitamin A and its metabolites modulate the balance between Th1 and Th2 immunity. In addition, vitamin D expresses protective effects on the innate immune system and inhibitory effects on adaptive immunity.
Type: Review
DOI: 10.5114/CEJI.2021.103540
ISSN: 14263912
SCOPUS: 85116242688
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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