Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/14241
Title: Assessment of the influence of expanded hemodialysis on the rate of removal of middle molecular weight uremic toxins
Authors: Nenadović, Marko
Nikolić, Aleksandra
Kostović, Milica
Drašković, Branislava
Jovanović, Milena
Nikolić, Tomislav
Petrovic, Dejan
Issue Date: 2020
Abstract: Objective. The aim of this study was to examine the effect of expanded hemodialysis on the degree of b2-microglobulin removal. Methods. Sixteen patients treated with extended MCO hemodialysis were examined. The main parameter for assessing the efficiency of removal of uremic toxins of middle molecular weight is the concentration of b2-microglobulin in the serum before and after a single session of extended MCO hemodialysis. The following were used for statistical analysis: Kolmogorov-Smirnov test, Student's T test for bound samples and Wilcoxon test. Results. Extended MCO hemodialysis effectively removes uremic toxins of middle molecular weight. The reduction index of b2-microglobulin during a single session of extended MCO hemodialysis is 70.60 ± 5.88%. The average loss of albumin during a single session of extended MCO hemodialysis is 1.88 ± 1.02 g/4h, and the index of albumin reduction is 4.94 ± 2.49%. Conclusion. Extended MCO hemodialysis effectively removes b2-microglobulin. The b2-microglobulin reduction index is ~ 71% and the albumin loss is less than 4.0 g/4h. This dialysis modality prevents the development of amyloidosis, atherosclerosis and atherosclerotic cardiovascular diseases in the population of patients treated with regular hemodialysis.
URI: https://scidar.kg.ac.rs/handle/123456789/14241
Type: article
DOI: 10.5937/mckg54-30496
ISSN: 0350-1221
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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