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Title: Dose-dependent effects of perfluorocarbon-based blood substitute on cardiac function in myocardial ischemia–reperfusion injury
Authors: Jakovljevic V.
Vorobyev, Sergey
Bolevich, Sergey
Morozova E.
Bolevich, Stephani Sergeevna
Saltykov A.
Litvickiy P.
Fisenko V.
Tsymbal, Alexander
Orlova A.
Sinelnikova T.
Kruglova, Maria
Silina, Ekaterina
Mikhaleva A.
Milosavljevic I.
Sretenovic J.
Stojic, Vladislava
Jeremic, Jovana
Nikolic Turnic T.
Issue Date: 2022
Abstract: The main goal of this study was to investigate the cardioprotective properties in terms of effects on cardiodynamics of perfluorocarbon emulsion (PFE) in ex vivo-induced ischemia–reperfusion injury of an isolated rat heart. The first part of the study aimed to determine the dose of 10% perfluoroemulsion (PFE) that would show the best cardioprotective effect in rats on ex vivo-induced ischemia–reperfusion injury of an isolated rat heart. Depending on whether the animals received saline or PFE, the animals were divided into a control or experimental group. They were also grouped depending on the applied dose (8, 12, 16 ml/kg body weight) of saline or PFE. We observed the huge changes in almost all parameters in the PFE groups in comparison with IR group without any pre-treatment. Calculated in percent, dp/dt max was the most changed parameter in group treated with 8 mg/kg, while the dp/dt min, SLVP, DLVP, HR, and CF were the most changed in group treated with 16 mg/kg 10 h before ischemia. The effects of 10% PFE are more pronounced if there is a longer period of time from application to ischemia, i.e., immediate application of PFE before ischemia (1 h) gave the weakest effects on the change of cardiodynamics of isolated rat heart. Therefore, the future of PFE use is in new indications and application methods, and PFE can also be referred to as antihypoxic and antiischemic blood substitute with mild membranotropic effects.
Type: article
DOI: 10.1007/s11010-022-04479-0
ISSN: 0300-8177
SCOPUS: 2-s2.0-85131076370
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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