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Title: Long-term trend of liver cancer mortality in Serbia, 1991–2015: An age-period-cohort and joinpoint regression analysis
Authors: Ilic, Irena
Grujicic J.
Grujicic J.
Radovanovic D.
Zivanovic-Macuzic, Ivana
Kocic, Sanja
Ilic, Milena
Issue Date: 2020
Abstract: Background and Objectives: Trends of liver cancer mortality vary widely around the world. The purpose of this study was to assess the trend of liver cancer mortality in Serbia. Material and Methods: Descriptive epidemiological study design was used in this research. The age-standardized rates (ASRs, per 100,000) were calculated using the direct method, according to the World standard population. Temporal trends were assessed using the average annual percent change (AAPC) with 95% confidence interval (95% CI), according to joinpoint regression. An age-period-cohort analysis was used to evaluate the underlying factors for liver cancer mortality trends. Results: In Serbia from 1991 to 2015, over 11,000 men and nearly 8000 women died from liver cancer. The trend in liver cancer mortality significantly decreased both in men (AAPC = −1.3%; 95% CI = −1.7 to −0.9) and women (AAPC = −1.5%; 95% CI = −1.9 to −1.1). For liver cancer mortality, statistically significant cohort and period effects were observed in both genders. Conclusions: The downward trends in liver cancer mortality in Serbia are recorded during the past decades.
Type: article
DOI: 10.3390/healthcare8030283
SCOPUS: 2-s2.0-85104257035
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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