Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/16338
Title: Plasma homocysteine concentrations in patients with Rheumatoid arthritis
Authors: Vasiljevic, Dragan
Tomic Lucic, Aleksandra
Živanović, Sandra
Milosavljevic, Milica
Radovanovic, Snezana
Anđelković, Nebojša
Djuric, Dragan M.
Veselinovic, Mirjana
Issue Date: 2015
Abstract: In this study, we investigated the concentration of serum homocysteine (Hcy) in patients with rheumatoid arthritis (RA) compared with the control group and the connection between homocysteine and parameters of inflammation and disease activity. Sixty RA patients and 20 healthy controls were included in the study, and clinical examination and investigation were performed during which disease activity was assessed. Peripheral blood samples were used for all of the assays. Levels of Hcy were 33% higher in the RA patients than in the control subjects (mean +/- SD 11.79±3.72 μmol/L versus 8.90±1.38 μmol/L; p< 0.01). A significant correlation was found between parameters of inflammation (C-reactive protein) and homocysteine in patients (r=0.322, p=0.012). Patients with high disease activity had a significantly greater increase in homocysteine (p<0.05). An increase in plasma homocysteine in RA patients is related to the parameters of inflammation and disease activity. Elevated Hcy levels occur commonly in patients with RA and may explain some of the increased cardiovascular mortality seen in RA patients.
URI: https://scidar.kg.ac.rs/handle/123456789/16338
Type: article
DOI: 10.1515/SJECR-2015-0027
ISSN: 1820-8665
SCOPUS: 2-s2.0-84943418382
Appears in Collections:Faculty of Hotel Management and Tourism, Vrnjačka Banja
Faculty of Medical Sciences, Kragujevac

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