Please use this identifier to cite or link to this item:
Title: Von Willebrand factor and oxidative stress parameters in acute coronary syndromes
Authors: Jakovljevic, Vladimir
Koprivica Z.
Djordjevic, Dusica
Vuletic, Milena
Zivkovic, Vladimir
Barudzic N.
Anđelković, Nebojša
Djuric, Dragan M.
Iric Cupic, Violeta
Krkeljic J.
Issue Date: 2011
Abstract: Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites-NO 2-), superoxide anion radical (O 2-), hydrogen peroxide (H 2O 2), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances-TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO 2-, H 2O 2, SOD and CAT activities were lower than controls'. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence. © 2011 Zoran Koprivica et al.
Type: article
DOI: 10.1155/2011/918312
ISSN: 1942-0900
SCOPUS: 2-s2.0-84860154464
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.