Combined machine learning and finite element simulation approach towards personalized model for prognosis of COVID-19 disease development in patients

Abstract

INTRODUCTION: Machine learning algorithms and in silico models for the COVID-19 have been used to classify infectious people and predict their condition in time. OBJECTIVES: This study aims at creating a personalized model that combines machine learning and finite element simulation approach in order to predict development of COVID-19 infection in patients. METHODS: The methodology combines several aspects (1) classification of patients into several classes of clinical condition (2) segmentation of human lungs in X ray images (3) finite element simulation to investigate the spreading of SARS-COV-2 virion in the lungs. RESULTS: The findings show accuracy larger than 90% in all aspects of methodology. FE simulation has revealed that the distribution of airflow in the lung changes in time with the infection. CONCLUSION: The key benefit of our proposed method is that it combines several methods that will be further improved in order to create a truly unique combined methodology for predictive models in patients infected with COVID-19.