Please use this identifier to cite or link to this item:
https://scidar.kg.ac.rs/handle/123456789/19100
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.rights.license | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.contributor.author | Matić, Sanja | - |
dc.contributor.author | Stanic, Snežana | - |
dc.date.accessioned | 2023-10-25T09:23:54Z | - |
dc.date.available | 2023-10-25T09:23:54Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | https://scidar.kg.ac.rs/handle/123456789/19100 | - |
dc.description.abstract | INTRODUCTION: Oxidative damage to DNA plays a crucial role in the progression and development of numerous diseases. Preventing DNA from oxidative damage is crucial for any living organism. OBJECTIVES: The present study was aimed to investigate the in vitro DNA protective effect of pinitol, a dietary inositol present in Ceratonia siliqua L., against hydroxyl and peroxyl radicals-induced oxidative DNA damage. Pinitol exhibits numerous pharmacological properties such as anticancer, antidiabetic, antioxidant, hepatoprotective, immunosuppressor, antiosteoporosis, antiaging, preventive and ameliorative of Alzheimer’s disease etc. METHOD / DESIGN: The protective activity of pinitol at various concentrations (25, 50, 100, and 200 μg/mL) was assayed in vitro using DNA from herring sperm as a model system, FeSO4 and H2O2 for the generation of hydroxyl radicals, (2-methylpropionamidine) dihydrochloride (AAPH) for oxidative DNA damage and assays for the detection of hydroxyl and peroxyl radicals-induced DNA damage. RESULTS: Pinitol showed DNA-protective effect at all tested concentrations against hydroxyl radical in a dose-dependent manner. Concentration-response of pinitol indicated that protection against peroxyl radical induced DNA damage was more significant with the increase in pinitol concentration. CONCLUSIONS: This investigation showed that pinitol can use as DNA protector against oxidative damage caused by hydroxyl and peroxyl radicals. | en_US |
dc.language.iso | en | en_US |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | International Bioscience Conference and the 8th International PSU-UNS Bioscience Conference | en_US |
dc.subject | Pinitol; DNA damage; hydroxyl radical; peroxyl radical | en_US |
dc.title | Pinitol as DNA protector against hydroxyl and peroxyl radicals-induced DNA damage | en_US |
dc.type | conferenceObject | en_US |
dc.description.version | Author's version | en_US |
dc.type.version | PublishedVersion | en_US |
Appears in Collections: | Institute for Information Technologies, Kragujevac |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
T1-P-45-IBSC-Book-of-Abstracts-2021-full.pdf | 243.27 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License