Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/19100
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dc.rights.licenseAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.contributor.authorMatić, Sanja-
dc.contributor.authorStanic, Snežana-
dc.date.accessioned2023-10-25T09:23:54Z-
dc.date.available2023-10-25T09:23:54Z-
dc.date.issued2021-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/19100-
dc.description.abstractINTRODUCTION: Oxidative damage to DNA plays a crucial role in the progression and development of numerous diseases. Preventing DNA from oxidative damage is crucial for any living organism. OBJECTIVES: The present study was aimed to investigate the in vitro DNA protective effect of pinitol, a dietary inositol present in Ceratonia siliqua L., against hydroxyl and peroxyl radicals-induced oxidative DNA damage. Pinitol exhibits numerous pharmacological properties such as anticancer, antidiabetic, antioxidant, hepatoprotective, immunosuppressor, antiosteoporosis, antiaging, preventive and ameliorative of Alzheimer’s disease etc. METHOD / DESIGN: The protective activity of pinitol at various concentrations (25, 50, 100, and 200 μg/mL) was assayed in vitro using DNA from herring sperm as a model system, FeSO4 and H2O2 for the generation of hydroxyl radicals, (2-methylpropionamidine) dihydrochloride (AAPH) for oxidative DNA damage and assays for the detection of hydroxyl and peroxyl radicals-induced DNA damage. RESULTS: Pinitol showed DNA-protective effect at all tested concentrations against hydroxyl radical in a dose-dependent manner. Concentration-response of pinitol indicated that protection against peroxyl radical induced DNA damage was more significant with the increase in pinitol concentration. CONCLUSIONS: This investigation showed that pinitol can use as DNA protector against oxidative damage caused by hydroxyl and peroxyl radicals.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourceInternational Bioscience Conference and the 8th International PSU-UNS Bioscience Conferenceen_US
dc.subjectPinitol; DNA damage; hydroxyl radical; peroxyl radicalen_US
dc.titlePinitol as DNA protector against hydroxyl and peroxyl radicals-induced DNA damageen_US
dc.typeconferenceObjecten_US
dc.description.versionAuthor's versionen_US
dc.type.versionPublishedVersionen_US
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