In vitro protective potential of the Lunaria annua L. aerial part and root extracts against DNA oxidative damage

Abstract

Lysimachia vulgaris L. (yellow or garden loosestrife) is a medicinal herb in the family Primulaceae that has been used in the treatment of fever, ulcer, diarrhea, dysentery, and wounds. It has been known as an analgesic, expectorant, anti-inflammatory, astringent, febrifuge, and demulcent agent. The present study aims to evaluate DNA protective properties of L. vulgaris aboveground part and root extracts against hydroxyl and peroxyl radicals-induced DNA damage. Results indicate that the DNA protective potential of extracts at various concentrations (25, 50, 100, 200, and 400 μg/mL) was in a concentration-dependent manner, increased with the concentration. These findings revealed L. vulgaris methanol extracts as a potent source of antioxidant agents against hydroxyl and peroxyl radicals.