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dc.rights.licenseAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.contributor.authorTodosijević, Jovana-
dc.contributor.authorLuković, Jovan-
dc.contributor.authorObradović, Jasmina-
dc.contributor.authorJurisic, Vladimir-
dc.date.accessioned2023-10-31T10:51:25Z-
dc.date.available2023-10-31T10:51:25Z-
dc.date.issued2020-
dc.identifier.isbn9788681652015en_US
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/19221-
dc.description.abstractEpidemiological data indicate that in the last period there has been an increase in the number of malignancies and among them lung cancer is one of the most common forms. In vitro studies based on the usage of immortalized cell lines are an important source of scientific knowledge for understanding of the mechanism of cell growth, proliferation and cell death. In this paper, the most commonly used methods for in vitro research in NSCLC (non-small cell lung cancer) based on testing the effects of new compounds to determine the degree of apoptosis, necrosis, cell proliferation as well as their significance are discussed. So far, techniques of working with monolayer cultures have been mainly used. In the future, it is recommended to use a 3D system, knockout cell line and to conduct additional studies regarding the use of organoids or spheroids, as well as the application of new techniques to better understand the complex processes of carcinogenesis and the action of biologically active compounds. Keywords: NSCLC, EGFR, cell line, mutation, in vitro method, MTT, Western blot, Flow cytometry, CRISP/casen_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourceRAP Conferenceen_US
dc.subjectNSCLCen_US
dc.subjectEGFRen_US
dc.subjectcell lineen_US
dc.subjectmutationen_US
dc.subjectin vitro methoden_US
dc.subjectMTTen_US
dc.subjectWestern bloten_US
dc.subjectFlow cytometryen_US
dc.subjectCRISP/casen_US
dc.titleBasic research of lung cancer in-vitro: measurement methods, new possibilities and perspectiveen_US
dc.typeconferenceObjecten_US
dc.description.versionPublisheden_US
dc.identifier.doi10.37392/RapProc.2020.11en_US
dc.type.versionPublishedVersionen_US
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