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dc.contributor.authorMatić, Sanja-
dc.contributor.authorŠmit, Biljana-
dc.contributor.authorStanić, Petar-
dc.contributor.authorPavlović, Radoslav-
dc.contributor.authorBađić, Jovica-
dc.date.accessioned2023-11-09T11:57:40Z-
dc.date.available2023-11-09T11:57:40Z-
dc.date.issued2023-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/19364-
dc.description.abstractA novel vase-shaped molecular basket 13-, consisting of a deep nonpolar pocket of three napthalimide molecules fused to a bicyclic base, with polar glycine residues at the top was synthesized. Biocompatibility of the synthesized molecular basket was examined in vitro. The possible in vitro DNA protective potential of the newly synthesized deep-cavity basket 13- at several concentrations (25, 50, 100, 200, and 400 μg/mL) was investigated against hydroxyl and peroxyl radicals-induced DNA damage. Basket at lower concentrations (25, 50, 100 μg/mL) almost completely protected DNA against hydroxyl and peroxyl radicals induced DNA damage. It can be concluded that the newly synthesized molecular basket in the range of concentrations tested showed a significant DNA-protective potential against oxidative modifications of DNA caused by the harmful effects of free radicals.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.source9th International Electronic Conference on Medicinal Chemistryen_US
dc.subjectmolecular basketsen_US
dc.subjectcavitanden_US
dc.subjectbiocompatibilityen_US
dc.subjectDNA protectionen_US
dc.titleNewly synthesized deep-cavity basket 13- as potential DNA protective agent against oxidative damageen_US
dc.typeconferenceObjecten_US
dc.description.versionPublisheden_US
dc.identifier.doi10.3390/ECMC2023-15631en_US
dc.type.versionPublishedVersionen_US
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