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dc.contributor.authorMrkalić, Emina-
dc.contributor.authorĆendić Serafinović, Marina-
dc.contributor.authorStojanović, Miroslav-
dc.contributor.authorSovrlic, Miroslav-
dc.contributor.authorJelic, Ratomir-
dc.date.accessioned2023-11-09T12:41:45Z-
dc.date.available2023-11-09T12:41:45Z-
dc.date.issued2021-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/19375-
dc.description.abstractHuman serum albumin (HSA) is a protein with a major role in the transportation and deposition of many ligands present in the blood. Many papers in science field deal with the interaction between drugs and HSA because those mechanisms are very important for understanding the pharmacokinetics and pharmacodynamics of drug pathways. Further, food components (such as flavonoids) may influence drug-HSA binding. It is known that flavonoids are polyphenolic secondary plant metabolites, which are very common in fruits and vegetables. Catechins are one of such representatives widely distributed in various groceries (green tea, red wine, juices, etc.). One of the most studied catechins is (+)-catechin due to its high abundance in the human diet and relevant antioxidant activity. Here, the binding affinity of tigecycline (TGC), tetracycline antibiotic, to HSA in the presence of (+)-catechin has been investigated by fluorescence and UV–Vis absorption spectroscopy under simulated physiological conditions (pH 7.4), and using molecular docking simulations. The main objective of the study was to reveal the mechanism of interactions and evaluate the influence of (+)-catechin on TGC-HSA binding. The presented study contributes to improving the current knowledge about the pharmacology of TGC in presence of food contents.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.source7th International Electronic Conference on Medicinal Chemistryen_US
dc.subjectTigecyclineen_US
dc.subjecthuman serum albuminen_US
dc.subject(+)-catechinen_US
dc.subjectfluorescenceen_US
dc.subjectUV–Vis spectroscopyen_US
dc.titleBinding of tigecycline to human serum albumin in the presence of (+)-catechinen_US
dc.typeconferenceObjecten_US
dc.description.versionPublisheden_US
dc.identifier.doi10.3390/ECMC2021-11366en_US
dc.type.versionPublishedVersionen_US
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