Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/19410
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dc.rights.licenseAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.contributor.authorMarjanović, Jovana S-
dc.contributor.authorRadisavljević, Snežana-
dc.contributor.authorDivac, Vera-
dc.contributor.authorKostic, Marina-
dc.date.accessioned2023-11-14T12:57:11Z-
dc.date.available2023-11-14T12:57:11Z-
dc.date.issued2023-
dc.identifier.citationJovana S. Marjanović, Snežana Radisavljević, Vera M. Divac, Marina D. Kostić, Synthesis and DNA binding properties of some new tryptamine Schiff’s bases, 9th Conference of Young Chemists of Serbia, Novi Sad Serbia, 4th November 2023en_US
dc.identifier.isbn978-86-7132-084-9en_US
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/19410-
dc.description.abstractThe synthesis of Schiff’s bases by reaction of tryptamine and seven different aldehydes has been performed in absolute ethanol. The required Schiff bases were obtained in good yields. Schiff bases are known as compounds with a wide range of biological activities, such as antifungal, antibacterial, anti-malarial, antiproliferative, anti-inflammatory and antipyretic [1]. In this study, we presented the synthesis and DNA binding properties of seven novel tryptamine-derived Schiff bases. UV-Vis spectroscopic method was used for the determination of the binding mode between exanimated substances and DNA. In order to obtain the binding strength of compounds to DNA molecules we’ve calculated intrinsic binding constants Kb (M−1) for tested compounds from the Wolfe–Shimmer equation [2]. All synthesized compounds showed high values for Kb (104 M−1) which indicates the strong binding of examined compounds to DNA.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.source9th Conference of Young Chemists of Serbiaen_US
dc.subjectSchiff baseen_US
dc.subjectTryptamineen_US
dc.subjectDNAen_US
dc.titleSynthesis and DNA binding properties of some new tryptamine Schiff’s basesen_US
dc.typeconferenceObjecten_US
dc.description.versionPublisheden_US
dc.type.versionPublishedVersionen_US
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