Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/20669
Title: ANTITUMOR EFFECTS OF TANACETUM BALSAMITA ESSENTIAL OILS BY DOWNREGULATION NRF-2 AND MMP-9 IN BREAST CANCER
Authors: Obradović, Ana
Vukić, Milena
Paunović, Milica
Ognjanović, Branka
Vukovic, Nenad
Kačániová, Miroslava
Matić, Miloš
Issue Date: 2024
Abstract: The aim of this study was to investigate antitumor capacity of different Tanacetum balsamita essential oils by measuring apoptosis rate, MMP-9 concetration and Nrf-2 expression level in human MBA-MB-468 and MDA-MB-231 cells. The tested EOs expressed proapoptotic effects, significantly inhibited the MMP-9 concentration and down-regulated the expression level of Nrf-2. The obtained data suggest that the tested EOs exert considerable antitumor activity elevating apoptosis level and inhibiting the motility of tested cancer cells. The reduced levels of Nrf-2 expression suggest decreased defense potential for oxidative disturbances, which could be the major antitumor mechanism detected in the study.
URI: https://scidar.kg.ac.rs/handle/123456789/20669
Type: conferenceObject
DOI: 10.46793/SBT29.71AO
Appears in Collections:Faculty of Science, Kragujevac

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