ASSESSMENT OF GALIUM VERUM EXTRACT SUPPLEMENTATION ON REDOX HOMEOSTASIS IN PSORIATIC RAT MODEL

Abstract

Psoriasis lacks comprehensive data on its systemic oxidative impact. This study explores Galium verum extract’s influence on systemic oxidative state in psoriatic rats. Twenty-four male W.albino rats were divided into control (CTRL), psoriasis (PSORI) and psoriasis treated with G.verum extract (PSORI+GV) groups. Blood samples analyzed for redox state biomarkers revealed increased TBARS levels in PSORI vs CTRL and PSORI+GV. PSORI exhibited significantly lower nitrite levels compared to CTRL and PSORI+GV, with elevated O2- and H2O2 levels. GSH and SOD values were reduced in PSORI and PSORI+GV, while catalase activity increased. G.verum extract positively modulated psoriatic rat redox state.