Study of Genotoxicity and Antigenotoxicity of the Cotinus coggygria Scop. Methanol Extract by Drosophila melanogaster Sex-Linked Recessive Lethal Test

Abstract

The genotoxic and antigenotoxic effects of Cotinus coggygria Scop. methanol extract was investi gated using the Drosophila sexlinked recessive lethal (or SLRL) test. The results presented here show that the methanol extract of Cotinus coggygria in a concentration of 5% and artificial chemical agent ethyl methane sulfonate EMS (0.75 ppm) induce recessive lethal mutations on Xchromosome on Drosophila melanogaster in all broods (I, II and III). Posttreatment with lower concentration of the methanol extract of Cotinus cog gygria (2%) was effective in reducing genotoxicity of mutagen.