Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/21156
Title: Synthesis, characterization, and biological evaluation of novel cobalt(II) complexes with β-diketonates: crystal structure determination, BSA binding properties and molecular docking study
Authors: Joksimović, Nenad
Petronijević, Jelena
Ćoćić, Dušan
Ristić, Marija
Mihajlović, Kristina
Janković, Nenad
Milović, Emilija
Klisurić, Olivera
Petrovic, Nevena
Kosanic, Marijana
Journal: JBIC Journal of Biological Inorganic Chemistry
Issue Date: 2024
Abstract: In order to discover a new antibiotic drug with better or similar activity of the already existing drugs, a series of novel cobalt(II) complexes with β-diketonate as ligands is synthesized and tested on four strains of bacteria and four species of fungi. All compounds showed notable antimicrobial activity against all tested strains. More importantly, some cobalt(II) complexes displayed greater activity than ketoconazole. It is important to notice that on the tested strains Mucor mucedo and Penicillium italicum complex 2B showed five times better activity compared to ketoconazole, while complex 2D had two times better activity on Penicillium italicum strain compared to ketoconazole. Moreover, investigations with bovine serum albumin were performed. Investigations showed that the tested complexes have an appropriate affinity for binding to bovine serum albumin. In addition, the molecular docking study was performed to investigate more specifically the sites and binding mode of the tested cobalt(II) complexes with β-diketonate as ligands to bovine serum albumin, tyrosyl-tRNA synthetase, topoisomerase II DNA gyrase, and cytochrome P450 14 alpha-sterol demethylase. In conclusion, all the results indicated the great prospective of the novel cobalt complexes for some potential clinical applications in the future.
URI: https://scidar.kg.ac.rs/handle/123456789/21156
Type: article
DOI: 10.1007/s00775-024-02069-7
ISSN: 1432-1327
SCOPUS: 55645524400
Appears in Collections:Faculty of Science, Kragujevac

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