DNA and HSA Binding Of Copper(II)-Complexes With Imine-Based Ferrocene Derivatives

Abstract

Copper, a crucial transition metal ion in biological systems, showcases distinctive redox activities and exhibits strong binding affinity toward nucleobases. In this study, three novel copper(II) complexes were synthesized and characterized, employing imine-based ferrocene derivatives as ligands. Characterization was achieved through MS and UV spectrophotometry, followed by an examination of the complexes' reactivity towards biomolecules. Specifically, the interaction of these complexes with CT-DNA and human serum albumin (HSA) were investigated. The findings demonstrate good CT-DNA and HSA interaction ability of the studied complexes. These results underscore the potential of incorporating imine-based ferrocene derivatives as ligands to enhance the stability and reactivity of copper(II) complexes. This research contributes to expanding the understanding of metal-ligand interactions in biological systems and offers insights into the design of novel metal-based therapeutics.