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Title: Influence of breastfeeding and timing of gluten introduction on the onset of celiac disease in infants
Authors: Mladenović M.
Radlovic N.
Leković Z.
Vuletić B.
Radlović V.
Dučić S.
Golubovic Z.
Radlović J.
Mahmutovic M.
Petrović J.
Issue Date: 2019
Abstract: © 2019, Serbia Medical Society. All rights reserved. Introduction/Objective The classic type of celiac disease (CD) is most common in children under two years of age. The aim of this study was to investigate whether breastfeeding, particularly breastfeeding during gluten introduction, and timing of gluten introduction, influence the onset of CD at this age. Methods We retrospectively analyzed medical records of 93 children, 40 in the first and 53 in the second year, with a classic CD diagnosed at the University Children’s Hospital, Belgrade between 2000 and 2010. The diagnosis of CD was based on the criteria of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) from 1989. Results Duration of breastfeeding reduced the onset of the CD in the first year p = 0.039 (OR = 1.43 95% CI 1.019–1.899). Also, breastfeeding at the time of gluten introduction significantly delayed the age at diagnosis (F = 1.671, t = 2.39, p = 0.029). The timing of gluten introduction did not affect the age of occurrence of CD in these group of children. Conclusion Longer breastfeeding, and breastfeeding at the time of gluten introduction, postponed the onset of classic CD in patients up to two years. The association between the occurrence of CD and the time of introduction of gluten in this age group of patients has not been established.
Type: article
DOI: 10.2298/SARH180904058M
ISSN: 0370-8179
SCOPUS: 2-s2.0-85077319348
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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