Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8303
Title: Clinical usefulness of<sup>99m</sup>tc-hynic-toc and<sup>131</sup>i-mibg scintigraphy in the evaluation of adrenal tumors
Authors: Vukomanovic V.
Matovic, Milovan
djukic, aleksandar
Ignjatovic, Vladimir
djukic, aleksandar
Vukomanović I.
Issue Date: 2019
Abstract: © 2019, University of Kragujevac, Faculty of Science. All rights reserved. Disorders and morphological abnormalities affecting the adrenal gland, could lead to profound clinical consequences, owing to its biochemical structure-activity and morphological characteristics. The recent focus on theranostic approach has led to a need for tumors characterization and early diagnosis at the molecular level. Many radiotracers have been developed with specific imaging characteristics for the adrenal tumors, by exploiting different physiological mechanisms of uptake and metabolism. The aim of present study is to provide a prospective confirmation of131I-MIBG and99mTc-HYNIC-TOC scintigraphy, for the evaluation of patients with known or suspected tumors of the adrenal region. The research is designed as a cross-sectional observational study of the clinical correlates and diagnostic accuracy of radionuclide-based imaging methods in relation to in vitro analysis, clinical manifestations and morphological characteristics of these tumors. Furthermore, the present study also evaluates the usefulness and the clinical impact of each radiopharmaceutical for the detection and management of tumors, and functional imaging modality as well. Visual scintigraphic appearance of an increased focal tracer uptake in the suspected tumor site revealed that99mTcHYNIC-TOC is highly sensitive and reliable tumor-seeking radiotracer for adrenal tumors, but does not distinguish between adenoma and pheochromocytoma, and the existence of hormone secreting adrenocortical tumor cells. However,131IMIBG scintigraphy is highly sensitive and specific method only in differentiating catecholamine-secreting adrenal tumors. Clinical significance of this research is in the accurate localization of adrenal tumors, and is of paramount importance for an algorithmic diagnostic approach and management, and provide the rationale to different therapeutic possibilities.
URI: https://scidar.kg.ac.rs/handle/123456789/8303
Type: article
DOI: 10.2478/SJECR-2018-0007
ISSN: 1820-8665
SCOPUS: 2-s2.0-85078940486
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)

67

Downloads(s)

6

Files in This Item:
File Description SizeFormat 
10.2478-SJECR-2018-0007.pdf482.37 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons