Please use this identifier to cite or link to this item:
Title: Phytochemical evaluation, antimicrobial and anticancer properties of new “oligo grapes” supplement
Authors: Ćurčić Milutinović, Milena
Vasić, Sava
Obradović, Ana
Zuher A.
Jovanovic M.
Radovanović M.
Čomić, Ljiljana
Marković, Snežana
Journal: Natural Product Communications
Issue Date: 1-Jan-2019
Abstract: © The Author(s) 2019 This research presents complete data about phytochemical analysis and biological activities of a new dietary supplement for commercial use “Oligo Grapes” (OG), and its individual constituents: lyophilized pomace (LP), clay supplemented with red wine extract, lyophilized pomace ethanolic extract (PE), and red wine extract. OG, as a commercially available food supplement, has not been previously tested for its biological activity. Now we want to present new data about its phytochemical screening, antioxidant and antibacterial activities, and anticancer properties with respect to its cytotoxicity and effects on redox status in colon cancer cell lines. The tested extracts expressed strong antibacterial activity against Proteus mirabilis and Proteus mirabilis ATCC 12453, where the synergy of contents inside the supplement demonstrated a higher influence on the bacteria than its separately tested constituents. Among the investigated extracts, PE, as the extract with the highest phenolics concentration, had remarkable cytotoxic activity on HCT-116 and SW-480 colon cancer cells. Also, the treatments modulated redox status in the investigated cancer cells, by inducing oxidative and nitrosative stress, which could be one of the preferred mechanisms of the anticancer action. Based on the achieved antimicrobial and anticancer properties, there is a need for producing different food supplements and nutritional products originating from grapes. In this respect, the food supplement OG and its health benefits deserve scientific attention and further research.
Type: Article
DOI: 10.1177/1934578X19860371
ISSN: 1934578X
SCOPUS: 85068615519
Appears in Collections:Faculty of Science, Kragujevac
[ Google Scholar ]

Page views(s)


Files in This Item:
File Description SizeFormat 
10.1177-1934578X19860371.pdf775.96 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.