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Title: Atherogenic impact of homocysteine: Can hmg-coa reductase inhibitors additionally influence hyperhomocysteinaemia?
Authors: Nikolic I.
Srejovic I.
Stojic, Isidora
Jeremic, Jovana
Folic, Marko
Matic, Aleksandar
Rakocevic M.
Jancic S.
Jakovljevic B.
Obrenović R.
Djuric D.
Zivkovic V.
Journal: Serbian Journal of Experimental and Clinical Research
Issue Date: 1-Jan-2019
Abstract: © 2019, University of Kragujevac, Faculty of Science. All rights reserved. The strong association among the risk of coronary artery diseases (CAD), high levels of LDL-C and low levels of HDL-C is well established. Hyperhomocysteinaemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) and causes endothelial dysfunction, a hallmark of atherosclerosis. In this study, we ascertained the influence of statins on the atherogenic index, as an indicator and a significant adjunct for predicting atherosclerosis in hyperhomocysteinaemic male Wistar albino rats. For 4 weeks, the animals were fed with one of the following diets (Mucedola SRL., Milan, Italy): standard rodent chow; a diet enriched in methionine with no deficiency in B vitamins or a diet enriched in methionine and deficient in B vitamins. The animals were simultaneously exposed to a pharmacology treatment with atorvastatin at dose of 3 mg/kg/day i.p. or simvastatin, at dose of 5 mg/kg/day i.p. We measured weight gain, food intake, and FER and determined the concentrations of biochemical parameters of dyslipidaemia (TC, TGs, LDL-C, VLDL-C, and HDL-C), AI, and CRR. A histopathological examination was conducted on portions of the right and left liver lobes from each animal. A connection between Hhcy and dyslipidaemia was indicated by the findings of biochemical and histological analyses, suggesting that Hhcy was a pro-atherogenic state. An improvement in the lipid profile along with a decrease in the atherogenic index by statins suggests that atorvastatin and simvastatin could be useful antiatherogenic agents, with protective activities during hyperhomocysteinaemia.
Type: Article
DOI: 10.1515/SJECR-2017-0055
ISSN: 18208665
SCOPUS: 85054776069
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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