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Title: Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart
Authors: Jeremić N.
Zivkovic V.
Srejovic I.
Jeremic, Jovana
Petkovic, Anica
Bradic, Jovana
Jakovljevic V.
Journal: Serbian Journal of Experimental and Clinical Research
Issue Date: 16-Feb-2018
Abstract: © 2017 Nevena Jeremic et al., published by De Gruyter Open. Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2-), superoxide anion radicals (O2-), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors. Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism. Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia.
DOI: 10.1515/sjecr-2017-0008
ISSN: 18208665
SCOPUS: 85042704408
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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