Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8605
Title: Risks of using sterilization by gamma radiation: The other side of the coin
Authors: Harrell C.
Djonov V.
Fellabaum, Crissy
Volarevic, Vladislav
Issue Date: 2018
Abstract: © Ivyspring International Publisher. The standard sterilization method for most medical devices over the past 40 years involves gamma irradiation. During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors. Accordingly, gamma radiation significantly alters biomechanical properties of bone, tendon, tracheal, skin, amnion tissue grafts and micronized amniotic membrane injectable products. Similarly, when polymer medical devices are sterilized by gamma radiation, their physico-chemical characteristics undergo modification significantly affecting their clinical use. Several animal studies demonstrated that consummation of irradiated food provoked genome instability raising serious concerns regarding oncogenic potential of irradiated consumables. These findings strongly suggest that new, long-term, prospective clinical studies should be conducted in near future to investigate whether irradiated food is safe for human consumption. In this review, we summarized current knowledge regarding molecular mechanisms responsible for deleterious effects of gamma radiation with focusing on its significance for food safety and biomechanical characteristics of medical devices, and tissue allografts, especially injectable biologics.
URI: https://scidar.kg.ac.rs/handle/123456789/8605
Type: article
DOI: 10.7150/ijms.22644
ISSN: 1449-1907
SCOPUS: 2-s2.0-85045221680
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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