Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8643
Title: Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract
Authors: Acovic A.
Gazdic, Marina
Jovicic, Nemanja
Harrell C.
Fellabaum, Crissy
Arsenijevic, Nebojsa
Volarevic, Vladislav
Journal: Therapeutic Advances in Gastroenterology
Issue Date: 1-Jan-2018
Abstract: © The Author(s), 2018. Indoleamine 2,3-dioxygenase (IDO) has the most important role in modulation of tryptophan-dependent effects in the gastrointestinal tract, including modulation of intestinal immune response. An increased IDO activity maintains immune tolerance and attenuates ongoing inflammation but allows immune escape and uncontrolled growth of gastrointestinal tumors. Accordingly, IDO represents a novel therapeutic target for the treatment of inflammatory and malignant diseases of the gastrointestinal tract. In this review article, we summarize current knowledge about molecular and cellular mechanisms that are involved in IDO-dependent effects. We provide a brief outline of experimental and clinical studies that increased our understanding of how enhanced IDO activity: controls host–microbiota interactions in the gut; regulates detrimental immune response in inflammatory disorders of the gastrointestinal system; and allows immune escape and uncontrolled growth of gastrointestinal tumors. Additionally, we present future perspectives regarding modulation of IDO activity in the gut as possible new therapeutic approaches for the treatment of inflammatory and malignant diseases of the gastrointestinal system.
URI: https://scidar.kg.ac.rs/handle/123456789/8643
Type: Review
DOI: 10.1177/1756284818815334
ISSN: 1756283X
SCOPUS: 85058434026
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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