Recommendations for treatment of non-infectious uveitis

Abstract

© 2018, Serbian Medical Society. All right reserved. Having in mind that ophthalmologists are coping with the problems of optimizing uveitis treatment on daily basis, there is a need for more precise elaboration of the treatment. This paper presents recommendations for the treatment of noninfectious uveitis on the basis of professional opinion, years of clinical experience in uveitology, and reference data. The recommendations are based on the SUN and IUSG criteria and are aimed at the development of a treatment algorithm. The treatment of non-infectious uveitis implies the management of acute attack, prevention of relapse and resolution of sequelae. Three treatment steps are identified: (1) the use of corticosteroids; (2) immunosuppressants and (3) biologicals. Each of the steps is associated with pertinent indications, dosage and the mode of administration. The treatment approach is based on etiology and severity of the disease as well as the inflammatory process level of activity. Corticosteroids are most commonly used as the first line of uveitis treatment. However, in more severe, refractory forms and because of associated local and systemic side effects, as well as dose-dependence, corticosteroids have been increasingly replaced with immunosuppressants and/or biological agents.