Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8754
Title: Extramedullary involvement of lymph nodes in multiple myeloma
Authors: Todorovic Z.
Jovanovic M.
Todorovic, Danijela
Ivosevic, Anita
Markovic M.
Radovanovic D.
Jovanovic, Danijela
Čemerikić V.
Djurdjevic, Predrag
Journal: Serbian Journal of Experimental and Clinical Research
Issue Date: 1-Sep-2017
Abstract: © 2017, University of Kragujevac, Faculty of Science. All rights reserved. Myeloma multiplex is a malignant disease of bone marrow plasma cells. It is usually confined to the bone marrow, but in rare cases, patients can develop extramedullary disease. The involvement of lymph nodes is rare and can be a diagnostic challenge. Here, we describe a 36-year-old male patient who presented with abdominal pain and discomfort initially. An abdominal ultrasound followed by computed tomography (CT) revealed retroperitoneal and mesenteric lymph node enlargement. Biopsies of the abdominal lymph node and infiltrated colon showed a plasma cell infiltrate positive for CD79α, CD38, CD138, kappa light chain and VEGF2. Multiple myeloma with extramedullary localization was diagnosed. After six cycles of chemotherapy consisting of doxorubicin, dexamethasone and thalidomide followed by autologous haematopoietic cell transplantation, the patient achieved complete remission. Specifically, a CT scan after therapy showed enlarged lymph nodes in the abdomen, but PET CT scans did not detect any metabolically active foci. Three years after the completion of therapy, the patient remains in remission. This case illustrates a rare presentation of extramedullary myeloma involving the abdominal lymph nodes, which could have been potentially mistaken for a lymphoid malignancy.
URI: https://scidar.kg.ac.rs/handle/123456789/8754
Type: Article
DOI: 10.1515/SJECR-2016-0081
ISSN: 18208665
SCOPUS: 85030723308
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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