Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8822
Title: Clinical benefits of n-3 PUFA and ɤ-linolenic acid in patients with rheumatoid arthritis
Authors: Veselinović M.
Vasiljevic, Dragan
Vucic, Vesna
Arsić A.
Petrović, Snježana
Tomic Lucic, Aleksandra
Savic M.
Zivanovic D.
Stojic, Vladislava
Jakovljevic V.
Journal: Nutrients
Issue Date: 1-Apr-2017
Abstract: © 2017 by the authors. (1) Background: Marine n-3 polyunsaturated fatty acids (PUFA) and ɤ-linolenic acid (GLA) are well-known anti-inflammatory agents that may help in the treatment of inflammatory disorders. Their effects were examined in patients with rheumatoid arthritis; (2) Methods: Sixty patients with active rheumatoid arthritis were involved in a prospective, randomized trial of a 12 week supplementation with fish oil (group I), fish oil with primrose evening oil (group II), or with no supplementation (group III). Clinical and laboratory evaluations were done at the beginning and at the end of the study; (3) Results: The Disease Activity Score 28 (DAS 28 score), number of tender joints and visual analogue scale (VAS) score decreased notably after supplementation in groups I and II (p < 0.001). In plasma phospholipids the n-6/n-3 fatty acids ratio declined from 15.47 ± 5.51 to 10.62 ± 5.07 (p = 0.005), and from 18.15 ± 5.04 to 13.50 ± 4.81 (p = 0.005) in groups I and II respectively. The combination of n-3 PUFA and GLA (group II) increased ɤ-linolenic acid (0.00 ± 0.00 to 0.13 ± 0.11, p < 0.001), which was undetectable in all groups before the treatments; (4) Conclusion: Daily supplementation with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.
URI: https://scidar.kg.ac.rs/handle/123456789/8822
Type: Article
DOI: 10.3390/nu9040325
SCOPUS: 85016258721
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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