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Title: Synthesis, characterization, and cytotoxicity of binuclear copper(Ii)-complexes with some s-alkenyl derivatives of thiosalicylic acid
Authors: Tomović D.
Bukonjić A.
Kocovic, Aleksandar
Nikolic, Milos
Mijajlovic M.
Jevtić, Verica
Ratković, Zoran
Arsenijevic A.
Milovanovic, Jelena
Stojanovic B.
Trifunović, Srećko
Radic G.
Issue Date: 2017
Abstract: © 2017, University of Kragujevac, Faculty of Science. All rights reserved. New complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (alkenyl = propenyl-(L1), isobutenyl-(L2)) have been synthesized and characterized by microanalysis, infrared spectra, magnetic measurements, and by NMR spectra. The cytotoxic activity of two newly synthesized precursor S-alkenyl derivatives of thiosalicylic acid were tested using an MTT colorimetric technique on HCT-116 human colon carcinoma cells. The cytotoxic effect of the copper(II)- complexes were higher compared to the cytotoxicity of the corresponding ligand (for concentrations from 31.25 to 250 μM). Copper(II)-complexes showed a slightly lower cytotoxicity compared to cisplatin. Complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (at concentrations from 250 to 1000 μM) had a cytotoxic effect on HCT-116 cells compared to cisplatin.
Type: article
DOI: 10.1515/SJECR-2016-0071
ISSN: 1820-8665
SCOPUS: 2-s2.0-85014810451
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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