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Title: Platinum complexes with edda ethylenediamine n, n diacetate ligands as potential anticancer agents
Authors: Jurisevic M.
Radosavljevic, Gordana
Arsenijevic A.
Milovanovic, Marija
Gajovic N.
Djordjevic, Dragana
Milovanovic, Jelena
Stojanovic B.
Ilic A.
Sabo, Tibor
Kanjevac, Tatjana
Issue Date: 2016
Abstract: © 2016, University of Kragujevac, Faculty of Science. All rights reserved. e design of platinum based drugs is not a new field of interest. Platinum complexes are widely used as anticancer agents and currently, approximately 30 platinum(II) and platinum(IV) entered into some of the phases of clinical trials. A special place in today’s research belongs to platinum complexes with diammine ligands. A large number of edda (ethylenediamine- N, N’-diacetate)-type ligands and their corresponding metal complexes has been successfully synthesized. is article summarizes recent progress in research on edda-type-platinum complexes. Some of these agents achieves better effect compared to the gold standard (cisplatin). It has been shown that there is a possible relationship between the length of the ligand ester group carbon chain and its cytotoxic effect. In most cases the longer the ester chain is the greater is the antitumor activity. Of particular interest are the noticeable effects of some new platinum compound with edda-type ligand on cell lines that are known to have a high level of cisplatin-resistance. Exanimate complexes appear to have a diff erent mode of mechanism of action compared with cisplatin which includes apoptotic and necrotic cell death. ere are indications that further investigations of these compounds may be very useful in overcoming the problems associated global cancer statistic.
Type: review
DOI: 10.1515/SJECR-2016-0042
ISSN: 1820-8665
SCOPUS: 2-s2.0-85006955548
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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