Please use this identifier to cite or link to this item:
Title: Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens
Authors: Ristic P.
Ranković B.
Kosanic, Marijana
Stanojkovic, Tatjana
Stamenković S.
Vasiljević, Perica
Manojlović I.
Manojlovic, Nedeljko
Issue Date: 2016
Abstract: © 2016, Association of Food Scientists & Technologists (India). The aim of this study was to investigate antioxidant, antimicrobial and anticancerous activity of Melanelia subaurifera and Melanelia fuliginosa. The phytochemical analysis was determined by HPLC–UV method. Antioxidant activity was evaluated by DPPH and reducing power assay while antimicrobial activity was determined by minimal inhibitory concentration. The cytotoxic activity was tested using MTT method. The method for quantification of 2′-O-methyl anziaic acid and lecanoric acid in these lichens using RF-HPLC was also developed and validated. The depsides (lecanoric acid, gyrophoric acid, atranorin, anziaic acid and 2′-O-methyl anziaic acid), and dibenzofurane (usnic acid) were identified in these lichens. The antioxidant activity (IC50) of lichens extracts ranged from 121.52 to 424.51 μg/ml. 2′-O-Methyl anziaic acid showed the highest antimicrobial activity with MIC ranging from 0.0625 to 1 mg/ml. M. subaurifera extract showed the highest cytotoxic activity against the tested cell lines (IC50 = 9.88 to 31.64 μg/ml).
Type: article
DOI: 10.1007/s13197-016-2255-3
ISSN: 0022-1155
SCOPUS: 2-s2.0-84975487570
Appears in Collections:Faculty of Science, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
10.1007-s13197-016-2255-3.pdf717.96 kBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons