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Title: Zinc and gold complexes in the treatment of breast cancer
Authors: Benazic S.
Silconi Z.
Milovanovic, Jelena
Arsenijevic A.
Stojanovic B.
Milovanovic, Marija
Kanjevac, Tatjana
Journal: Serbian Journal of Experimental and Clinical Research
Issue Date: 1-Mar-2016
Abstract: © 2016, University of Kragujevac, Faculty of Science. All Rights Reserved. Metals are essential components in indispensable biochemical processes for living organisms. This review article highlights the metals zinc and gold in the development and treatment of breast cancer. Metal compounds off er many advantages as therapeutics due to their ability to coordinate ligands in a three-dimensional confi guration. In aqueous solution, they form positively charged ions that can bind to negatively charged biological molecules. Metal complexes that contain metal ions such as zinc(II) and gold have received considerable attention as potential anticancer agents. Zinc is an essential trace element that plays a critical role in a wide range of cellular processes that include structural, signalling, catalytic and regulatory functions. Zinc acts as a key structural component in many proteins and enzymes, including transcription factors, cellular signalling proteins, and DNA repair enzymes, and perturbed levels of zinc in tissues may play a role in cancer aetiology and outcome. Unlike zinc, gold is feasible as a component of compounds for eff ective anticancer therapy. Some progress in anticancer therapy may include interactions between zinc and gold.
Type: Review
DOI: 10.1515/SJECR-2015-0044
ISSN: 18208665
SCOPUS: 84961572503
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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