Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9185
Title: Mesenchymal stem cells in regenerative rehabilitation
Authors: Nurkovic J.https
Dolicanin Z.
Mustafic F.
Mujanovic R.
Memic, Mensur
Grbovic, Vesna
Jurisic Skevin, Aleksandra
Nurkovic J.https
Journal: Journal of Physical Therapy Science
Issue Date: 1-Jan-2016
Abstract: © 2016 The Society of Physical Therapy Science. [Purpose] Regenerative medicine and rehabilitation contribute in many ways to a specific plan of care based on a patient’s medical status. The intrinsic self-renewing, multipotent, regenerative, and immunosuppressive properties of mesenchymal stem cells offer great promise in the treatment of numerous autoimmune, degenerative, and graft-versus-host diseases, as well as tissue injuries. As such, mesenchymal stem cells represent a therapeutic fortune in regenerative medicine. The aim of this review is to discuss possibilities, limitations, and future clinical applications of mesenchymal stem cells. [Subjects and Methods] The authors have identified and discussed clinically and scientifically relevant articles from PubMed that have met the inclusion criteria. [Results] Direct treatment of muscle injuries, stroke, damaged peripheral nerves, and cartilage with mesenchymal stem cells has been demonstrated to be effective, with synergies seen between cellular and physical therapies. Over the past few years, several researchers, including us, have shown that there are certain limitations in the use of mesenchymal stem cells. Aging and spontaneous malignant transformation of mesenchymal stem cells significantly affect the functionality of these cells. [Conclusion] Definitive conclusions cannot be made by these studies because limited numbers of patients were included. Studies clarifying these results are expected in the near future.
URI: https://scidar.kg.ac.rs/handle/123456789/9185
Type: review
DOI: 10.1589/jpts.28.1943
ISSN: 09155287
SCOPUS: 84975463120
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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