Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9276
Title: Transport of low-density lipoprotein into the blood vessel wall during atherogenic diet in the isolated rabbit carotid artery
Authors: Colic M.
Pantović S.
Jeremic M.
Jokovic V.
Obradović Z.
Rosic, Mirko
Journal: Circulation Journal
Issue Date: 1-Jan-2015
Abstract: © 2015, Japanese Circulation Society. All rights reserved. Background: Atherosclerosis is a chronic fibroproliferative disease that includes accumulation of cholesterol-rich lipids in the arterial wall. Though numerous studies have investigated atherosclerosis, not enough is known about the exact mechanisms of low-density lipoprotein (LDL) transport into the blood vessel wall. Therefore, we explored the 125I-LDL transport into the arterial wall under constant perfusion flow and pressure as well as the influence of duration of atherogenic diet on 125I-LDL transport and biomechanical properties of carotid artery. Methods and Results: The isolated segment of rabbit carotid artery was used under constant perfusion flow and pressure-induced (0 mmHg and 140 mmHg) blood vessel distension, with the possibility to change and precisely calculate shear stress during the experiment. Obtained results indicate the influence of atherogenic diet duration and consequent variation of shear stress on 125I-LDL transport into the blood vessel wall. 125I-LDL transport into the blood vessel wall at low pressure-induced blood vessel distension decreases by the increase of the shear stress and in relation to the atherogenic diet duration. At high pressure-induced blood vessel distension, 125I-LDL transport increases in relation to the atherogenic diet duration and the increase of shear stress. Conclusions: The influence of shear stress is a more dominant parameter on LDL uptake at low pressure-induced blood vessel distension; however, the atherogenic diet duration has more of a dominant influence on LDL uptake at high pressure-induced vessel distension.
URI: https://scidar.kg.ac.rs/handle/123456789/9276
Type: Article
DOI: 10.1253/circj.CJ-14-1316
ISSN: 13469843
SCOPUS: 84937862678
Appears in Collections:Faculty of Medical Sciences, Kragujevac
[ Google Scholar ]

Page views(s)

48

Downloads(s)

3

Files in This Item:
File Description SizeFormat 
10.1253-circj.CJ-14-1316.pdf766.29 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.