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Title: Population pharmacokinetic of antiepileptic drugs in different populations
Authors: Milovanovic, Jasmina
Jankovic, Slobodan
Issue Date: 2013
Abstract: This article reviews a population pharmacokinetics studies conducted during the past few years in Serbia. Studies have included three the most frequently used antiepileptic drugs (valproate, carbamazepine and lamotrigine) and different populations of epileptic patients: children, adults and heterogeneous population composed of both children and adults. The review compares obtained values of population pharmacokinetic models of clearance of these drugs, and factors that are significantly determined, making brief comments on the results of other authors on the same topic. Individualization of drug dosage is the basis of rational therapy, and factors of variability will always be subject of scientific research. © 2013 Versita Warsaw and Springer-Verlag Berlin Heidelberg.
Type: review
DOI: 10.2478/s11536-013-0158-5
ISSN: 1895-1058
SCOPUS: 2-s2.0-84879218614
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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