Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9514
Title: Correlation between micronuclei frequency in peripheral blood lymphocytes and retention of 131-I in thyroid cancer patients
Authors: Vrndic O.
Milošević-Đorđević, Olivera
Mijatovic Teodorovic, Ljiljana
Jeremic M.
Stosic I.
Grujičić, Darko
Zivancevic-Simonovic, Snezana
Journal: Tohoku Journal of Experimental Medicine
Issue Date: 1-Feb-2013
Abstract: Differentiated thyroid cancers (DTCs) derive from thyroid follicular cells and include papillary and follicular cancers. In patients with DTCs, the initial treatment includes thyroidectomy and radioactive iodine (131-I) therapy. The objective of this study was to examine whether the intensity of DNA damage in peripheral blood lymphocytes (PBLs) of DTC patients depends on the amount of 131-I retained in the selected regions of interest (thyroid and abdominal region) as well as in the whole-body 72 hours after therapy. In addition, the possible influence of other factors that may affect micronuclei (MN) frequency, such as age, gender, smoking habits, and histological type of tumour was analyzed. The study population consisted of 22 DTC patients and 20 healthy donors. Data on the distribution of 131-I were obtained from the whole-body scans. MN frequency and cytokinesis-block proliferation index (CBPI) were measured using cytokinesis-block micronucleus assay. 131-I therapy significantly increased the MN frequency (19.50 ± 6.90 vs. 27.10 ± 19.50 MN) and significantly decreased the CBPI (1.52 ± 0.20 vs. 1.38 ± 0.17) in patients' lymphocytes. There was a clear correlation between the increased MN frequency and 131-I accumulation in the thyroid region in patients without metastases. The MN values did not differ in relation to the factors that could affect MN, such as age, gender, smoking habits, and histological type of tumour. In conclusion, the MN frequency in PBLs of DTC patients without metastases depends on the accumulation of 131-I in the thyroid region and does not depend on the other factors examined. © 2013 Tohoku University Medical Press.
URI: https://scidar.kg.ac.rs/handle/123456789/9514
Type: journal article
DOI: 10.1620/tjem.229.115
ISSN: 00408727
SCOPUS: 84876320825
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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