Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9663
Title: Human stem cell research and regenerative medicinepresent and future
Authors: Volarevic, Vladislav
Ljujic, Biljana
Stojkovic P.
Lukic, Aleksandra
Arsenijevic, Nebojsa
Stojkovíc M.
Journal: British Medical Bulletin
Issue Date: 1-Sep-2011
Abstract: Introduction: Stem cells are cells with the ability to grow and differentiate into more than 200 cell types. Sources of data: We review here the characteristics and potential of human embryonic stem cells (hESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs). Areas of agreement: The differentiation ability of all stem cell types could be stimulated to obtain specialized cells that represent renewable sources of functional cells useful for cell-based therapy. Areas of controversy: The proof of functional differentiated cells needs to be investigated in more detail using both in vitro and in vivo assays including animal disease models and clinical studies. Growing points: Much progress has been made in the ASCs-based therapies. Meanwhile hESCs and iPSCs have dramatically emerged as novel approaches to understand pathogenesis of different diseases. Areas timely for developing research: A number of new strategies become very important in regenerative medicine. However, we discuss the limitations of stem cells and latest development in the reprogramming research. © The Author 2010. Published by Oxford University Press. All rights reserved.
URI: https://scidar.kg.ac.rs/handle/123456789/9663
Type: Article
DOI: 10.1093/bmb/ldr027
ISSN: 00071420
SCOPUS: 80052700737
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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