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Title: A novel caryophyllene type sesquiterpene lactone from Asparagus falcatus (Linn.); Structure elucidation and anti-angiogenic activity on HUVECs
Authors: Ghalib R.
Rokiah H.
Sulaiman, Othman
Mehdi S.
Valkonen A.
Rissanen K.
Trifunović, Srećko
Khadeer Ahamed, Mohamed B
Abdul Majid, Amin Malik Shah
Kawamura F.
Issue Date: 2012
Abstract: In this study the novel caryophyllene type sesquiterpene lactone (aspfalcolide) has been isolated from the leaves of Asparagus falcatus (Linn.) and characterized by IR, 1D NMR, 2D NMR, EI-MS, HR-ESI-MS and X-ray single crystal diffraction analysis. The aspfalcolide crystallizes in the orthorhombic space group P2 12 12 1 with a = 6.37360(10), b = 7.6890(2), c = 27.3281(6) , α = β = γ = 90 ° and Z = 4. One intermolecular O-H⋯O hydrogen bond enforces these natural molecules to form infinite chains through the crystal. Aspfalcolide was screened for its anti-angiogenic activity in human umbilical vein endothelial cells (HUVECs) and the result showed the remarkable inhibitory effect of aspfalcolide on the proliferation (IC 50 1.82 μM), migration and tube formation of HUVECs. © 2011 Elsevier Masson SAS. All rights reserved.
Type: article
DOI: 10.1016/j.ejmech.2011.10.037
ISSN: 0223-5234
SCOPUS: 2-s2.0-84855759484
Appears in Collections:Faculty of Science, Kragujevac

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