Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMarković, Snežana-
dc.contributor.authorŽižić, Jovana-
dc.contributor.authorŠeklić, Dragana-
dc.contributor.authorObradović, Ana-
dc.contributor.authorĆurčić Milutinović, Milena-
dc.contributor.authorCvetkovic, Danijela-
dc.contributor.authorĐorđević, Nevena-
dc.contributor.authorOgnjanovic, Branka-
dc.contributor.authorŠtajn A.-
dc.description.abstractIn this study we evaluated the possible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats chronically treated with cisplatin (cisPt). Four groups of Wistar albino rats were examined: a control, untreated rats (I), rats treated with Se (II), rats treated with cisPt (III), and rats treated with Se and cisPt (IV). All animals were treated for 5 days successively and killed 24 h after the last treatment. Hematological and oxidative stress parameters were followed in whole blood and red blood cells (RBC). Results showed that the chronic application of Se was followed by a higher number of reticulocytes and platelets, increased lipid peroxidation and GSH content in the RBC. Cisplatin treatment induced depletion of RBC and platelet numbers and an elevation of the superoxide anion, nitrites and glutathione levels. Se and cisPt co-treatment was followed by an elevation of the hematological parameters and the recovery of the glutathione status when compared to the control and cisPt-treated rats.-
dc.relation.ispartofArchives of Biological Sciences-
dc.titleAlteration of oxidative stress parameters in red blood cells of rats after chronic in Vivo treatment with cisplatin and selenium-
dc.typejournal article-
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
0354-46641104991M.pdf633.95 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.