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Title: Contractile effects of endothelins on isolated human ureter
Authors: Jankovic, Slobodan
Jankovic O.
Stojanovic V.
Stojadinovic, Dobrivoje
Stojadinovic, Miroslav
Canovic D.
Stefanovic, Srdjan
Issue Date: 2011
Abstract: The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35×10-11 M - 5.05×10-8 M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of human ureter. Endothelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ETA receptors BQ123 and selective antagonist of ETB receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA2=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA2=8.68 and 7.02, respectively), while they did not affect endothelin-1- induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ETA and ETB receptors, the first one being functionally more important. Only endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ETA and ETB receptors. © 2011 Institute of Physiology.
Type: article
DOI: 10.33549/physiolres.932144
ISSN: 0862-8408
SCOPUS: 2-s2.0-84856496012
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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