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Title: Stereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(4- methyl)pentanoic acid
Authors: Vujic J.
Kaluerovic G.
Milovanovic, Marija
Zmejkovski B.
Volarevic, Vladislav
Zivić D.
Urević P.
Arsenijevic, Nebojsa
Trifunović, Srećko
Issue Date: 2011
Abstract: Platinum(II) complexes (1-4) with bidentate N,N′-ligands, O,O′-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N′-di-2-(4-methyl)pentanoic acid were synthesized and characterized by IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. DFT calculations were performed for the complexes and it was found that only one diastereoisomer could be formed. Cytotoxic activity of complexes 1-4 was determined against chronic lymphocytic leukemia cells (CLL) and compared to the activity of ligand precursors L1·2HCl-L4·2HCl and corresponding palladium(II) complexes, [PdCl 2L] (L = L1-L4). The complexes were found to exhibit significantly higher antitumor activities than cisplatin on CLL cells. Cytotoxic effect of platinum(II) complexes on CLL cells was higher compared to corresponding palladium(II) complexes. In addition the mode of cell death induced by platinum(II) complexes was determined. © 2011 Elsevier Masson SAS. All rights reserved.
Type: article
DOI: 10.1016/j.ejmech.2011.07.034
ISSN: 0223-5234
SCOPUS: 2-s2.0-80052931979
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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