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Title: Fatigue and depression in multiple sclerosis: Correlation with quality of life
Authors: Miletic Drakulic, Svetlana
Toncev, Gordana
Jevdjic, Jasna
Jovanović, Boris
Canovic D.
Journal: Archives of Biological Sciences
Issue Date: 11-Aug-2011
Abstract: The aim of this work was to examine the relationship between fatigue and depression, common features of multiple sclerosis (MS), and the quality of life (QOL). The study was comprised of 120 patients with clinical manifestations of definite MS. Relapsing-remitting MS was present in 76.7% patients and secondary progressive MS was present in 23.3% patients. Mean disease duration was 8.1 ± 5.6 years and the mean Expanded Disability Status Score (EDSS) was 3.5 ± 1.8 (range 1-8). Fatigue was measured with the Fatigue Severity Scale (FSS), depression was measured by the Beck Depression Inventory (BDI) and QOL was assessed using the health-related quality of life questionnaire SF-36. We observed that the global FSS score was 4.6 ± 1.8 (range 1-7) and BDI was 10.7 ± 10.3 (range 0-39). The FSS significantly and positively correlated with the BDI scores (r = 0.572; p = 0.000). The severity of fatigue had a significant impact on the quality of life (r = -0.743; p = 0.000), in particular on mental health (r = -0.749; p = 0.000). We observed a significant correlation between the severity of depression and impaired quality of life (r = -0.684; p = 0.000). This study shows that fatigue and depression are associated with impaired QOL in MS.
Type: Article
DOI: 10.2298/ABS1103617M
ISSN: 03544664
SCOPUS: 79961198724
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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