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Title: Intravenous immunoglobulins exposed to heme (heme IVIG) are more efficient than IVIG in attenuating autoimmune diabetes
Authors: Pavlović, Nenad
Zdravkovic, Nemanja
Dimitrov J.
djukic, aleksandar
Arsenijevic, Nebojsa
Vassilev T.
Lukic, Miodrag
Issue Date: 2011
Abstract: Intravenous immunoglobulins (IVIG) are known to have a therapeutic effect in some autoimmune diseases. We examined the effect of IVIG and heme-exposed IVIG on the development of immune mediated diabetes induced in C57BL/6 mice by multiple low doses of streptozotocin. IVIG were used in a dose of 200mg/kg daily for 15days. Treatment with IVIG resulted in significant attenuation of diabetes induction as evaluated by glycemia, glycosuria and HbA1c level. Interestingly, heme-exposed IVIG had a still stronger antidiabetogenic effect. Serum levels of proinflammatory cytokines TNF-α, IFN-γ and IL17 were lower in IVIG treated animals when compared with controls, while IL10 level was higher. The number of CD4+Foxp3+ cells was higher in pancreatic lymph nodes of heme-exposed IVIG treated mice. Our results show that IVIG may downregulate diabetes induction possibly by favouring induction of T regulatory cells and suggest enhanced effect upon heme-binding to IVIG. © 2010 Elsevier Inc.
Type: article
DOI: 10.1016/j.clim.2010.10.010
ISSN: 1521-6616
SCOPUS: 2-s2.0-79251598193
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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