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Title: Role of Galectin-3 in Tumour Metastasis
Authors: Radosavljevic, Gordana
Jovanovic I.
Knezevic M.
Zdravkovic, Nemanja
Pavlovic S.
Lukic, Miodrag
Arsenijevic, Nebojsa
Issue Date: 2010
Abstract: We used metastatic variant of B16 melanoma (B16F1) to study lung colonization galectin-3-deficient (gal-3-/-) C57BL/6 mice. In vivo study showed that compared with gal-3+/+ mice, gal-3-/-mice exhibited resistance to lung colonization of B16F1 melanoma cells (p < 0.03). In vitro assays showed higher number of attached malignant cells in the tissue section derived from gal-3+/+ mice (p < 0.001) and tumor specific cytotoxicity of lymphoid cells of tumour inoculated gal-3-/- suggesting that galectin-3 is considered as therapeutic target. © 2010 Allerton Press, Inc.
Type: article
DOI: 10.3103/S0027131410030107
ISSN: 0027-1314
SCOPUS: 2-s2.0-77956608737
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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