Role of Galectin-3 in Tumour Metastasis

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Назив:	Role of Galectin-3 in Tumour Metastasis
Аутори:	Radosavljevic, Gordana Jovanovic I. Knezevic M. Zdravkovic, Nemanja Pavlovic S. Lukic, Miodrag Arsenijevic, Nebojsa
Датум издавања:	2010
Сажетак:	We used metastatic variant of B16 melanoma (B16F1) to study lung colonization galectin-3-deficient (gal-3-/-) C57BL/6 mice. In vivo study showed that compared with gal-3+/+ mice, gal-3-/-mice exhibited resistance to lung colonization of B16F1 melanoma cells (p < 0.03). In vitro assays showed higher number of attached malignant cells in the tissue section derived from gal-3+/+ mice (p < 0.001) and tumor specific cytotoxicity of lymphoid cells of tumour inoculated gal-3-/- suggesting that galectin-3 is considered as therapeutic target. © 2010 Allerton Press, Inc.
URI:	https://scidar.kg.ac.rs/handle/123456789/10163
Тип:	article
DOI:	10.3103/S0027131410030107
ISSN:	0027-1314
SCOPUS:	2-s2.0-77956608737
Налази се у колекцијама:	Faculty of Medical Sciences, Kragujevac