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Title: Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats
Authors: Mihailovic, Vladimir
Mihailovic, Mirjana
Uskoković, Aleksandra
Arambašić Jovanović, Jelena
Mišić D.
Stankovic, Vesna
Katanić Stanković, Jelena S.
Mladenović M.
Solujic A.
Matić, Sanja
Journal: Food and Chemical Toxicology
Issue Date: 1-Feb-2013
Abstract: This study is an attempt to evaluate the hepatoprotective activity of Gentiana asclepiadea L. against carbon tetrachloride-induced liver injury in rats. Methanol extracts of aerial parts (GAA) and roots (GAR) of G. asclepiadea at doses of 100, 200, and 400mg/kgb.w. were orally administered to Wistar rats once daily for 7days before they were treated with CCl4. The hepatoprotective activity of the extracts in this study was compared with the reference drug silymarin. In CCl4 treated animals, GAA and GAR significantly decreased levels of serum transaminases, alkaline phosphatase and total bilirubin, and increased the level of total protein. Treatment with the extracts resulted in a significant increase in the levels of catalase, superoxide dismutase and reduced glutathione, accompanied with a marked reduction in the levels of malondialdehyde, as compared to CCl4 treated group. The histopathological studies confirmed protective effects of extracts against CCl4-induced liver injuries. No genotoxicity was observed in liver cells after GAA treatment, while GAR showed only slight genotoxic effects by comet assay. Phytochemical analysis revealed the presence of sweroside, swertiamarin and gentiopicrin in high concentrations in both extracts. It could be concluded that the use of G. asclepiadea extracts in the treatment of chemical-induced hepatotoxicity. © 2012 Elsevier Ltd.
Type: Article
DOI: 10.1016/j.fct.2012.10.034
ISSN: 02786915
SCOPUS: 84870316596
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac
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